Initiated in 2007, the SET-UP project is an ongoing epidemiologic evaluation of heart failure patients evaluated in the Stanford Exercise Laboratory. Studies from SET-UP have provided important insights into the application of cardiopulmonary exercise test responses in unique patient populations including hypertrophic cardiomyopathy, dilated cardiomyopathy, optimizing normal standards for peak VO2, and the prognostic utility of non-invasive hemodynamic measurements during exercise. This is a sampling of some of the publications from this project.

Myers J, Kaminsky L, Lima R, Christle J, Ashley E, Arena R. A reference equation for normal standards for VO2 max: Analysis from the Fitness Registry and the Importance of Exercise Database (FRIEND Registry). Progress in Cardiovascular Diseases 60:21-29, 2017.

Myers J, Wong M, Adhikarla C, Boga M, Challa S, Abella J, Ashley EA. Cardiopulmonary and non-invasive hemodynamic responses to exercise predict outcomes in heart failure. J Cardiac Failure 19:101-107, 2013.

Finocchiaro G, Haddad F, Knowles J, Pavlovic A, Sinagra G, Wong M, Perez M, Myers J, Froelicher V, Ashley E. Cardiopulmonary responses and prognosis in hypertrophic cardiomyopathy: A potential role for comprehensive non-invasive hemodynamic assessment. JACC Heart Failure 3:408-418, 2015.

Finocchiaro G, Haddad F, Kobayashi Y, Lee D, Pavlovic A, Schnittger I, Sinagra G, Magavern E, Myers J, Froelicher V, Knowles J, Ashley E. Impact of septal reduction on left atrial size and diastole in hypertrophic cardiomyopathy. Echocardiography 33:686-694, 2016.

Moneghetti K, Kobayashi Y, Christle J, Ariyama M, Vrtovec B, Kouznetsove T, Wilson A, Myers J, Ashley E, Wheeler M, Haddad F. Contractile reserve and cardiopulmonary exercise testing parameters in patients with dilated cardiomyopathy. The two dimensions of exercise testing. Echocardiography 34:1179-1186, 2017.

Moneghetti KJ, Stolfo D, Christle JW, Kobayashi Y, Finocchiaro G, Sinagra G, Myers J, Ashley EA, Haddad F, Wheeler MT. Value of strain imaging and maximal oxygen consumption in patients with hypertrophic cardiomyopathy. Am J Cardiol 120:1203-1208, 2017.

Moneghetti KJ, Kobayashi Y, Christle JW, Ariyama M, Vrtovec B, Kouznetsova T, Wilson A, Ashley E, Wheeler MT, Myers J, Haddad F. Contractile reserve and cardiopulmonary exercise parameters in patients with dilated cardiomyopathy, the two dimensions of exercise testing. Echocardiography 34:1179-1186, 2017.

Moneghetti KJ, Giraldeau G, Wheeler MT, Kobayashi Y, Vrtovec B, Boulate D, Kuznetsova T, Schnittger I, Wu JC, Myers J, Ashley E, Haddad F. Incremental value of right heart metrics and exercise performance to well-validated risk scores in dilated cardiomyopathy. Eur Heart J Cardiovasc Imaging 19:916-925,2017.

Moneghetti KJ, Christle JW, Myers J, Haddad F. Exercise testing in heart failure: a contemporary discussion in an era of novel diagnostic techniques and biomarkers.

Curr Opin Cardiol 33:217-224, 2018.

Moneghetti KJ, Hock J, Kaminsky L, Arena R, Lui GK, Haddad F, Wheeler M, Froelicher V, Ashley E, Myers J, Christle JW. Applying current normative data to prognosis in heart failure: The Fitness Registry and the Importance of Exercise National Database (FRIEND). Int J Cardiol 263:75-79, 2018.

Myers J, Christle J, Tun A, Yilmaz B, Moneghetti KJ, Yuen E, Soofi M, Ashley E. Cardiopulmonary exercise testing, impedance cardiography, and reclassification of risk in heart failure. J Cardiac Failure 25:961-968, 2019.

Hershman SG, Bot BM, Shcherbina A, Doerr M, Moayedi Y, Pavlovic A, Waggot D, Cho MK, Rosenberger ME, Haskell WL, Myers J, Champagne MA, Mignot E, Landray M, Tarassenko L, Harrington RA, Yeung AC, McConnell MV, Ashley EA. Physical activity, sleep and cardiovascular health data for 50,000 individuals from the MyHeart Counts study. Sci Data 6:24, 2019.

Nishi T, Kobayashi Y, Christle JW, Cauwenberghs N, Boralkar K, Moneghetti K, Amsallem M, Hedman K, Contrepois K, Myers J, Mahaffey KW, Schnittger I, Kuznetsova T, Palaniappan L, Haddad F. Incremental value of diastolic stress test in identifying subclinical heart failure in patients with diabetes mellitus. Eur Heart J Cardiovasc Imaging 21:876-88, 2020.

Olivotto I, Oreziak A, Barriales-Villa A, Abraham TP, Masri A, Garcia-Pavia P, Saberi S, Lakdawala NK, Wheeler MT, Owens A, Kubanek M, Wojakowski W, Jensen M, Gimeno-Blanes J, Afshar K, Myers J, Hegde SM, Sehnert AJ, Zhang D, Li W, Bhattacharya M, Edelberg JM, Burstein-Waldman C, Lester SJ, Wang A, Ho CY, Jacoby D, on behalf of EXPLORER-HCM Study Investigators. Mavacamten in symptomatic obstructive hypertrophic cardiomyopathy. Lancet, 396; (10253):759-769, 2020.

Kobayashi Y, Nishi T, Christle J, Hedman K, Boralkar K, Moneghetti K, Amsallem M, Cauwenberghs N, Schnittger I, Mahaffey K, Kuznetsova T, Faroqi L, Myers J, Palaniappan L, Haddad F. Inverse association between change in age-predicted peak VO2 and risk of hospital readmission in patients with coronary heart disease, European Heart Journal, in press, 2021.

Kobayashi Y, Christle J, Contrepois K, Nishi T, Moneghetti K, Cauwenberghs N, Myers J, Kuznetsova T, Palaniappan L, Haddad F. Peripheral oxygen extraction and exercise limitation in asymptomatic patients with diabetes mellitus. Am J Cardiol, 149:132-139, 2021.

Myers J, de Souza e Silva C, Arena R, Kaminsky L, Christle JW, Busque V, Ashley E, Moneghetti K. Comparison of the FRIEND and Wasserman-Hansen equations in predicting outcomes in heart failure. J Amer Heart Assoc, in press, 2021.